Phenobarbital, also known as phenobarbitone or phenobarb, is a medication recommended for the treatment of certain types of epilepsy in developing countries In the developed world it is commonly used to treat seizures in young children, while other medications are generally used in older children and adults. It may be used intravenously, injected into a muscle, or taken by mouth. The injectable form may be used to treat status epilepticus. It is occasionally used to treat trouble sleeping, anxiety, and drug withdrawal and to help with surgery.

Medical uses
It is used in the treatment of all types of seizures except absence seizures. It is no less effective at seizure control than phenytoin, however phenobarbital is not as well tolerated. It may provide a clinical advantage over carbamazepine for treating partial onset seizures. Carbamazepine may provide a clinical advantage over phenobarbital for generalized onset tonic-clonic seizures.

It  is the first-line choice for the treatment of neonatal seizures.

It is sometimes used for alcohol detoxification and benzodiazepine detoxification for its sedative and anticonvulsant properties. The benzodiazepines chlordiazepoxide (Librium) and oxazepam (Serax) have largely replaced phenobarbital for detoxification.

It’s properties can effectively reduce tremors and seizures associated with abrupt withdrawal from benzodiazepines.

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