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JWH-250 is a synthetic cannabinoid receptor agonist that has been detected in products since the late 2000s. It was created by Dr. John W. Huffman and a report on it was released in 2005 by Huffman et al.

The drug is a phenylacetylindole and it works as an agonist at CB1 and CB2 receptors. It has an affinity of ~11 nM at CB1 and ~33 nM at CB2

It is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid and peripheral cannabinoid receptors. This product has been identified as a component of several different ‘herbal incense’ products often marketed as ‘not for human consumption’. Belonging to the synthetic cannabinoid receptor agonists (SCRAs) category of drugs, it has similar effects to those of THC. The quantity of JWH-250 within a package can vary significantly, increasing the likelihood of overdose as users are not fully aware of what is contained inside these herbal products. Reported effects of overdose include tachycardia, hypertension, agitation, hallucinations, minor elevation of blood glucose, hypokalemia and vomiting.

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