Probenecid

Description

Probenecid

Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.

It was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.

It is primarily used to treat gout and hyperuricemia.

It is sometimes used to increase the concentration of some antibiotics. Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it is combined with probenecid.

It has also found use as a masking agent, potentially helping athletes using performance-enhancing substances to avoid detection by drug tests.

Some of the important clinical interactions of probenecid include those with captopril, indomethacin, ketoprofen, ketorolac, naproxen, cephalosporins, quinolones, penicillins, methotrexate, zidovudine, ganciclovir, lorazepam, and acyclovir. In all these interactions, the excretion of these drugs is reduced due to probenecid.

This product is intended for forensic and research applications.
This product has been manufactured and tested to meet ISO17025:2005 and Guide 34:2009 guidelines
This product is intended to be used as an analytical reference standard
Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing

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